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Tri-Hospital Research Ethics Board

The Tri-Hospital Research Ethics Board (THREB) is a shared research ethics board serving Cambridge Memorial Hospital, Grand River Hospital and St. Mary's General Hospital. THREB reviews all research involving human subjects at these hospitals, except for research reviewed by an alternate Board of Record for one of the hospitals (e.g. the Ontario Cancer Research Ethics Board).
 
In order to facilitate this review, all the necessary documentation must be included in the application (see forms below).
 
THREB meets the first Wednesday of the month except during July and August. A completed application package including the signed original and 5 copies (6 copies in total) must be received by the second Wednesday of the month prior to the meeting date. A checklist outlining the required steps is included as the first part of the application form.
 
Minimal risk studies that may receive delegated (expedited) review instead of full board review have no deadline for receipt.
 
The primary responsibility of the THREB is to make decisions concerning the ethical acceptability of research proposed by the hospital(s), by researchers having an association with the hospital(s), or any research involving patients or staff at the hospital(s). For purposes of review by THREB, research is defined as "an undertaking intended to extend knowledge through a disciplined or systematic investigation" (Tri-Council Policy Statement 2).
 
THREB is mandated to approve, reject, propose modifications to, or terminate any proposed or ongoing research involving human subjects that is conducted within the hospitals, again with the exception of research reviewed by an alternate Board of Record for the hospital(s). THREB complies with guidelines from
  • The Tri-Council Policy Statement Ethical Conduct for Research Involving Humans 2 (2010)
  • The Good Clinical Practice: Consolidated Guideline of the International Conference on Harmonization
  • Division 5 Health Canada Food and Drug Regulations
  • Relevant Canadian health and privacy legislation
THREB also endeavours to facilitate compliance with the human subject requirements of two US federal agencies: The Food and Drug Administration and the Office for Human Research Protections, US Dept of Health and Human Services.
 
Additional administrative review
While THREB reviews all research, administration departments at each hospital also review research for financial, resource, and contractual implications (see administrative approval form application Part 3).
 
Please note: Each hospital has a unique process for administrative review and approval. This process must be completed before THREB review can be initiated. It is up to the Investigator to make contact with the relevant institutions to determine their requirements. Contact information for administrative review at the three hospitals can be found below and in the administrative approval form (application part 3).
 
Cambridge Memorial Hospital
Susan Gregoroff, Vice President, Clinical Programs and Chief Nursing Executive
700 Coronation Boulevard, Cambridge, Ontario N1R 3G2
Telephone: 519.621.2333 extension 2315
sgregoroff@cmh.org
 
Grand River Hospital
Karen Cavrag, Project Manager
835 King Street West, Kitchener, Ontario, N2G 1G3
Telephone: 519-749-4300 extension 3999
research@grhosp.on.ca
 
St. Mary's General Hospital
Lydia Chudleigh, Vice President: Quality and Performance Management
911 Queen's Boulevard, Kitchener, Ontario N2M 1B2
Telephone: 519-749-6403
lchudleigh@smgh.ca
 
Both the administrative review and the research ethics board review must be completed and any outstanding issue resolved prior to the research being initiated.

For more information, or to send an application and other forms, contact
 
Laurie Dietrich, THREB Administrative Coordinator, Tri-Hospital Research Ethics Board
Grand River Hospital, Kaufman Building K503,
835 King Street West, Kitchener, ON N2G 1G3
Phone: 519-749-4300, extension 5367
Fax: 519-749-4274
 
You can reach the THREB Chairperson, Dr. Michael D. Coughlin at: coughlin.michael@gmail.com
 
More information is available under the following links:
Forms
In general, the THREB requires the original and five copies (6 packages in total) of all documents that must be reviewed. To provide sufficient time for review, completed application packages and other items for review must be received by the second Wednesday of the month prior to the THREB meeting date. Please email an electronic copy of the submission to laurie.dietrich@grhosp.on.ca

The PDF files are for information purposes only. Forms must be filled by typing using the Word files.
 

Application materials

Download*

Application form for project review (revised January 2014)

Application for retrospective review of health records (revised January 2014)

Administrative approval form (Application - Part 3) (revised January 2014)


Forms for Continuing Review

 

 

Annual Renewal Progress Report Form (revised July 2014)

Amendment Review Request Form (revised January 2014)

Study Completion Form (revised January 2014)

Unanticipated Problems - SAE Report Form (revised January 2014)

Confidentiality agreements (revised January 2014)

*To download these files without opening in your browser:
Right-click the icon associated with the chosen file and select "Save Target As" from the drop down menu.
(Mac users, click and hold mouse button until the drop down menu appears, then choose "Save Target As")
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