The Tri-Hospital Research Ethics Board (THREB) is a shared research ethics board serving Cambridge Memorial, Grand River and St. Mary's General hospitals. THREB reviews all research involving human subjects at these hospitals, except for some cancer research reviewed by a province-wide board.
In order to facilitate this review, all the necessary documentation must be included in the application (see forms below).
THREB meets the first Wednesday of the month except during July and August. Completed application package must be received by the second Wednesday of the month prior to the meeting date. A checklist outlining the required steps is included as the first part of the application form.
THREB’s primary responsibility is to make decisions concerning the ethical acceptability of research proposed by the hospital(s), by researchers having an association with the hospital(s), or any research involving patients or staff at the hospital(s). For the purposes of review by THREB, research is defined as "an undertaking intended to extend knowledge through a disciplined or systematic investigation" (Tri-Council Policy Statement 2).
THREB is mandated to approve, reject, propose modifications to, or terminate any proposed or ongoing research involving human subjects that is conducted with a hospital. THREB complies with guidelines from
- The Tri-Council Policy Statement Ethical Conduct for Research Involving Humans
- The Good Clinical Practice: Consolidated Guideline of the International Conference on Harmonization
- Division 5 Health Canada Food and Drug Regulations
- Relevant Canadian health and privacy legislation
THREB also endeavours to facilitate compliance with the human subject requirements of two US federal agencies: The Food and Drug Administration and the Office for Human Research Protections, US Dept of Health and Human Services.
Additional administrative review
While THREB reviews all research, administration departments at each hospital also review research for financial, resource, and contractual implications (see administrative approval form application Part 3).
Please note: Each hospital has a unique process for administrative review and approval. This process must be completed before THREB review can be initiated. It is up to the Investigator to make contact with the relevant institutions to determine their requirements. Contact information for administrative review at the three hospitals can be found below and in the administrative approval form (application part 3).
Cambridge Memorial Hospital
Susan Gregoroff, Vice President, Clinical Programs and Chief Nursing Executive
700 Coronation Boulevard, Cambridge, Ontario N1R 3G2
Telephone: 519.621.2333 extension 2315
sgregoroff@cmh.org
Grand River Hospital
Kelly McDonnell, Quality Improvement Consultant
835 King Street West, Kitchener, Ontario, N2G 1G3
Telephone: 519-749-4300 extension 5159
research@grhosp.on.ca
St. Mary's General Hospital
Lydia Chudleigh, Vice President: Quality and Performance Management
911 Queen's Boulevard, Kitchener, Ontario N2M 1B2
Telephone: 519-749-6403
lchudleigh@smgh.ca
Both the administrative review and the research ethics board review must be completed and any outstanding issue resolved prior to the research being initiated.
For more information, or to send an application and other forms, contact
Laurie Dietrich (Schulze), THREB Administrative Coordinator, Tri-Hospital Research Ethics Board
Grand River Hospital, Kaufman Building K503,
835 King Street West, Kitchener, ON N2G 1G3
Phone: 519-749-4300, extension 5367
Fax: 519-749-4274
More information is available under the following links:
Forms
In general, the THREB requires the original and five copies of all documents that must be reviewed. To provide sufficient time for review, completed application packages and other items for review must be received by the second Wednesday of the month prior to the THREB meeting date. Please email an electronic copy of the submission to laurie.dietrich@grhosp.on.ca
The PDF files are for information purposes only. Forms must be filled by typing using the word files.
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Application materials |
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Application form for project review (revised January 2013) |
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Application for retrospective review of health records (revised January 2013) |
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Administrative approval form (Application - Part 3) (revised January 2013) |
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Forms for Continuing Review
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Annual Renewal Progress Report Form (revised January 2013) |
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Amendment Review Request Form (revised January 2013) |
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Study Completion Form (revised January 2013) |
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SAE Report Form (revised January 2013) |
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Confidentiality agreements (revised January 2013)
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